The Special Issue on “Human Factors in Green Building” addresses the design of indoor environment quality for users’ needs. The collected papers cover various building types and the research highlights the different needs of users. In working environments, employees’ stress is the main concern in the workplace design, especially for open plan offices where lack of privacy and over exposure to environmental stress have been reported. In residential environments, residents have great opportunities to adjust their environments to suit their needs; therefore, passive design such as natural ventilation is explored in residential buildings with climates such as cold or humid tropical. In healthcare environments, the papers in this issue are concerned with the needs of patients, especially the older adults who require special care. In learning environments, thermal and visual aspects are investigated for optimal comfort conditions and learning outcomes. The special issue demonstrates insightful critical thinking of indoor environment quality and proposes a new understanding for more practical design solutions.